Fiore breaks her research down into four pillars: air pollution, chemistry-climate connections, trends and variability in atmospheric constituents, and biosphere-atmosphere interactions. She uses a range of models alongside remote sensing and in situ observations to understand tropospheric ozone chemistry, its sensitivity to different sources and sinks including the terrestrial biosphere, on hourly and local scales up to global and decadal dimensions.  Fiore and her group also investigate regional meteorology and climate feedbacks due to aerosols vs greenhouse gases, future air pollution responses to climate change, as well as the factors controlling the oxidizing capacity of the atmosphere.  As a member of the NASA Health and Air Quality Applied Sciences Team, she partners with air and health management groups to address emerging needs with applications of satellite and other Earth science datasets.